LAN LABDuke University
The work

Publications

Featured discoveries

Suppression of transcription-replication conflicts by sequence-coordinated actions of TRDMT1 and MutLα

Nat Commun · 2026

DOI

ABL1-mediated tyrosine phosphorylation of SYCP2 contributes to transcription-coupled homologous recombination and platinum resistance in ovarian cancer

NAR Cancer · 2025

DOI

cGAS restricts PARP1-mediated microhomology-mediated end joining by suppressing poly-ADP-ribosylation

Cell Death Differ · 2026

DOI

All publications

2026

  • Suppression of transcription-replication conflicts by sequence-coordinated actions of TRDMT1 and MutLα

    Ghosh A, Ran X, Zhang F, Gao B, Xu Y, Phoon LY, Long M, Wang M, Ananthapadmanabhan V, Kawale A, Shah Y, Manzano-Winkler B, Ott CJ, Zou L, Lan L

    Nat Commun 17

    DOI

  • cGAS restricts PARP1-mediated microhomology-mediated end joining by suppressing poly-ADP-ribosylation

    Yang H, Gao B, Wu B, Li W, Zhu X, Phoon L, Luo J, Gui F, Zhao W, Jia L, Lan L

    Cell Death Differ 33:1252-1263

    DOI

  • HELZ is a RNA-DNA helicase that resolves R loops to facilitate homologous recombination repair

    Haji-Seyed-Javadi R, Koyen AE, Rath SK, Wu B, Madden MZ, Hou Y, Kapoor-Vazirani P, Roshika R, Aiello M, Luong NC, Tseng WC, Sesay F, Kim JS, Tan T, Kim S, Gao B, Song BS, Kenney AM, Connolly EC, Yang L, Xhemalce B, Li X, Switchenko JM, Yang X, Buchwald ZS, Deng X, Miller KM, Yao B, Lan L, Zhao W, Yu DS

    Nat Commun 17

    DOI

  • HELZ-BRCA2 complex resolves R-loops to drive transcription-coupled homologous recombination

    Li W, Wu B, Gao B, Irvin EM, Ghosh A, Eliaz L, Huang Y, Kwon Y, Stiefel CM, Nguyen TTN, Zhao D, Suarez HJ, Ni T, Alejo S, Fitzgerald O, Song X, Rath SK, Wasmuth EV, Yu DS, Zheng S, Leung J, Xue X, Wang H, Ji JH, Lan L, Zhao W

    Nat Commun 17

    DOI

  • ABL kinase inactivation induces transcription-replication conflicts and impairs replication fork progression in metastatic small cell lung cancer

    Gu JJ, Scott KM, Ghosh A, Barbier RH, Rouse DC, Hoj JP, Caminear MW, Zhang F, Gao B, Barbier MW, Zou L, Lan L, Pendergast AM

    Cell Rep 45:117699

    DOI

  • Multifaceted roles of PDS5B in RAD51-dependent homology-directed DNA repair and replication fork protection

    Katz JN, Samentar L, Fang Q, Ji JH, Li W, Gao Q, Kuppa S, Gao B, Rogers CM, Kaur H, Shabestari AB, Dutta A, Syed S, Tovar M, Tomimatsu N, Mukherjee B, Irvin EM, Zhou S, Habib AA, Libich DS, Hromas R, Mazin AV, Rao MK, Olsen SK, Wasmuth EV, Losada A, Zhou D, Wang H, Lan L, Greene EC, Zhao W, Kwon Y, Burma S, Sung P

    Nat Commun 17

    DOI

  • ATM counteracts chromatin-bound cGAS during DNA replication

    Song Y, Ran X, Xu Y, Subramanian K, Dai C, Konstantinos M, Lan L, Yadav V, Zou L

    Nat Cell Biol 28:946-956

    DOI

  • SonoPIN enables precise, noninvasive, and efficient intracellular delivery of PROTACs

    Wu Y, Liu M, Li K, Li S, Phoon LY, Mai J, Chen Y, Yan W, Lan SN, Rufo J, Milford G, He Y, Wu Q, Yang S, Lan L, Benkovic SJ, Huang TJ

    Proc Natl Acad Sci U S A 123:e2534439123

    DOI

2025

  • Transcription-coupled DNA repair protects genome stability upon oxidative stress-derived DNA strand breaks

    Yang H, Lan L

    FEBS Lett 599:168-176

    DOI

  • ABL1-mediated tyrosine phosphorylation of SYCP2 contributes to transcription-coupled homologous recombination and platinum resistance in ovarian cancer

    Gao B, Wang X, Long M, Zhang F, Wang Y, Kumar R, Veillard I, Rueda BR, Yeku O, Lan L

    NAR Cancer 7:zcaf031

    DOI

  • ZNF280A links DNA double-strand break repair to human 22q11.2 distal deletion syndrome

    Clarke TL, Cho HM, Ceppi I, Gao B, Yadav T, Silveira GG, Boon R, Martinez-Pastor B, Amoh NYA, Machin B, Bernasocchi T, Ashfaq D, Mendez J, Kamaliyan Z, Del Río Pantoja J, Rogines GS, Crowley BT, McGinn DE, Giunta V, Tran O, Zackai EH, Lan L, Zou L, Emanuel BS, McDonald-McGinn DM, Cejka P, Mostoslavsky R

    Nat Cell Biol 27:1006-1020

    DOI

2024

  • DSS1 restrains BRCA2's engagement with dsDNA for homologous recombination, replication fork protection, and R-loop homeostasis

    Huang Y, Li W, Foo T, Ji JH, Wu B, Tomimatsu N, Fang Q, Gao B, Long M, Xu J, Maqbool R, Mukherjee B, Ni T, Alejo S, He Y, Burma S, Lan L, Xia B, Zhao W

    Nat Commun 15:7081

    DOI

  • Meiotic protein SYCP2 confers resistance to DNA-damaging agents through R-loop-mediated DNA repair

    Wang Y, Gao B, Zhang L, Wang X, Zhu X, Yang H, Zhang F, Zhu X, Zhou B, Yao S, Nagayama A, Lee S, Ouyang J, Koh SB, Eisenhauer EL, Zarrella D, Lu K, Rueda BR, Zou L, Su XA, Yeku O, Ellisen LW, Wang XS, Lan L

    Nat Commun 15:1568

    DOI

  • The FANCI/FANCD2 complex links DNA damage response to R-loop regulation through SRSF1-mediated mRNA export

    Olazabal-Herrero A, He B, Kwon Y, Gupta AK, Dutta A, Huang Y, Boddu P, Liang Z, Liang F, Teng Y, Lan L, Chen X, Pei H, Pillai MM, Sung P, Kupfer GM

    Cell Rep 43:113610

    DOI

  • Revisiting Aurora Kinase B: A promising therapeutic target for cancer therapy

    Lakkaniga NR, Wang Z, Xiao Y, Kharbanda A, Lan L, Li HY

    Med Res Rev 44:686-706

    DOI

2023

  • HELZ promotes R loop resolution to facilitate DNA double-strand break repair by homologous recombination

    Haji-Seyed-Javadi R, Koyen AE, Rath SK, Madden MZ, Hou Y, Song BS, Kenney AM, Lan L, Yao B, Yu DS

    bioRxiv

    DOI

  • ATR inhibition induces synthetic lethality in mismatch repair-deficient cells and augments immunotherapy

    Wang M, Ran X, Leung W, Kawale A, Saxena S, Ouyang J, Patel PS, Dong Y, Yin T, Shu J, Manguso RT, Lan L, Wang XF, Lawrence MS, Zou L

    Genes Dev 37:929-943

    DOI

  • The RNA m5C modification in R-loops as an off switch of Alt-NHEJ

    Yang H, Lachtara EM, Ran X, Hopkins J, Patel PS, Zhu X, Xiao Y, Phoon L, Gao B, Zou L, Lawrence MS, Lan L

    Nat Commun 14:6114

    DOI

  • The DACH1 gene is frequently deleted in prostate cancer, restrains prostatic intraepithelial neoplasia, decreases DNA damage repair, and predicts therapy responses

    Li Z, Jiao X, Robertson AG, Di Sante G, Ashton AW, DiRocco A, Wang M, Zhao J, Addya S, Wang C, McCue PA, South AP, Cordon-Cardo C, Liu R, Patel K, Hamid R, Parmar J, DuHadaway JB, Jones SJM, Casimiro MC, Schultz N, Kossenkov A, Phoon LY, Chen H, Lan L, Sun Y, Iczkowski KA, Rui H, Pestell RG

    Oncogene 42:1857-1873

    DOI

  • The DACH1 gene is frequently deleted in prostate cancer, restrains prostatic intraepithelial neoplasia, decreases DNA damage repair, and predicts therapy responses

    Li Z, Jiao X, Robertson AG, Sante GD, Ashton AW, DiRocco A, Wang M, Zhao J, Addya S, Wang C, McCue PA, South AP, Cordon-Cardo C, Liu R, Patel K, Hamid R, Parmar J, DuHadaway JB, Jones SJ, Casimiro MC, Schultz N, Kossenkov A, Phoon LY, Chen H, Lan L, Sun Y, Iczkowski KA, Rui H, Pestell RG

    Res Sq

    DOI

2022

  • Immunostaining and Protein Pull-Down of Methyl-5-Cytosine-Marked RNA:DNA Hybrids

    Yang H, Lan L

    Methods Mol Biol 2528:271-276

    DOI

  • Author Correction: Sources, resolution and physiological relevance of R-loops and RNA-DNA hybrids

    Petermann E, Lan L, Zou L

    Nat Rev Mol Cell Biol 23:444

    DOI

  • Sources, resolution and physiological relevance of R-loops and RNA-DNA hybrids

    Petermann E, Lan L, Zou L

    Nat Rev Mol Cell Biol 23:521-540

    DOI

  • FMRP promotes transcription-coupled homologous recombination via facilitating TET1-mediated m5C RNA modification demethylation

    Yang H, Wang Y, Xiang Y, Yadav T, Ouyang J, Phoon L, Zhu X, Shi Y, Zou L, Lan L

    Proc Natl Acad Sci U S A 119:e2116251119

    DOI

  • DNA repair defects in cancer and therapeutic opportunities

    Hopkins JL, Lan L, Zou L

    Genes Dev 36:278-293

    DOI

2021

  • Alternative lengthening of telomeres is a self-perpetuating process in ALT-associated PML bodies

    Zhang JM, Genois MM, Ouyang J, Lan L, Zou L

    Mol Cell 81:1027-1042.e4

    DOI

  • Ubiquitination-mediated degradation of TRDMT1 regulates homologous recombination and therapeutic response

    Zhu X, Wang X, Yan W, Yang H, Xiang Y, Lv F, Shi Y, Li HY, Lan L

    NAR Cancer 3:zcab010

    DOI

  • RNA transcripts stimulate homologous recombination by forming DR-loops

    Ouyang J, Yadav T, Zhang JM, Yang H, Rheinbay E, Guo H, Haber DA, Lan L, Zou L

    Nature 594:283-288

    DOI

2020

  • Cigarette smoke exposure enhances transforming acidic coiled-coil-containing protein 2 turnover and thereby promotes emphysema

    Mallampalli RK, Li X, Jang JH, Kaminski T, Hoji A, Coon T, Chandra D, Welty S, Teng Y, Sembrat J, Rojas M, Zhao Y, Lafyatis R, Zou C, Sciurba F, Sundd P, Lan L, Nyunoya T

    JCI Insight 5

    DOI

  • An R-loop-initiated CSB-RAD52-POLD3 pathway suppresses ROS-induced telomeric DNA breaks

    Tan J, Duan M, Yadav T, Phoon L, Wang X, Zhang JM, Zou L, Lan L

    Nucleic Acids Res 48:1285-1300

    DOI

  • The DNA secondary structures at telomeres and genome instability

    Tan J, Lan L

    Cell Biosci 10:47

    DOI

  • Resolution of ROS-induced G-quadruplexes and R-loops at transcriptionally active sites is dependent on BLM helicase

    Tan J, Wang X, Phoon L, Yang H, Lan L

    FEBS Lett 594:1359-1367

    DOI

  • m(5)C modification of mRNA serves a DNA damage code to promote homologous recombination

    Chen H, Yang H, Zhu X, Yadav T, Ouyang J, Truesdell SS, Tan J, Wang Y, Duan M, Wei L, Zou L, Levine AS, Vasudevan S, Lan L

    Nat Commun 11:2834

    DOI

  • An ordered assembly of MYH glycosylase, SIRT6 protein deacetylase, and Rad9-Rad1-Hus1 checkpoint clamp at oxidatively damaged telomeres

    Tan J, Wang X, Hwang BJ, Gonzales R, Konen O, Lan L, Lu AL

    Aging (Albany NY) 12:17761-17785

    DOI

  • cGAS suppresses genomic instability as a decelerator of replication forks

    Chen H, Chen H, Zhang J, Wang Y, Simoneau A, Yang H, Levine AS, Zou L, Chen Z, Lan L

    Sci Adv 6

    DOI

2019

  • Localized protein biotinylation at DNA damage sites identifies ZPET, a repressor of homologous recombination

    Moquin DM, Genois MM, Zhang JM, Ouyang J, Yadav T, Buisson R, Yazinski SA, Tan J, Boukhali M, Gagné JP, Poirier GG, Lan L, Haas W, Zou L

    Genes Dev 33:75-89

    DOI

  • Phosphatase 1 Nuclear Targeting Subunit Mediates Recruitment and Function of Poly (ADP-Ribose) Polymerase 1 in DNA Repair

    Wang F, Zhu S, Fisher LA, Wang L, Eurek NJ, Wahl JK 3rd, Lan L, Peng A

    Cancer Res 79:2526-2535

    DOI

  • Binding of FANCI-FANCD2 Complex to RNA and R-Loops Stimulates Robust FANCD2 Monoubiquitination

    Liang Z, Liang F, Teng Y, Chen X, Liu J, Longerich S, Rao T, Green AM, Collins NB, Xiong Y, Lan L, Sung P, Kupfer GM

    Cell Rep 26:564-572.e5

    DOI

  • Alternative Lengthening of Telomeres through Two Distinct Break-Induced Replication Pathways

    Zhang JM, Yadav T, Ouyang J, Lan L, Zou L

    Cell Rep 26:955-968.e3

    DOI

2018

  • SIRT6 facilitates directional telomere movement upon oxidative damage

    Gao Y, Tan J, Jin J, Ma H, Chen X, Leger B, Xu J, Spagnol ST, Dahl KN, Levine AS, Liu Y, Lan L

    Sci Rep 8:5407

    DOI

  • ELL2 regulates DNA non-homologous end joining (NHEJ) repair in prostate cancer cells

    Zang Y, Pascal LE, Zhou Y, Qiu X, Wei L, Ai J, Nelson JB, Zhong M, Xue B, Wang S, Yang D, Lan L, Shan Y, Wang Z

    Cancer Lett 415:198-207

    DOI

  • RAD52 is required for RNA-templated recombination repair in post-mitotic neurons

    Welty S, Teng Y, Liang Z, Zhao W, Sanders LH, Greenamyre JT, Rubio ME, Thathiah A, Kodali R, Wetzel R, Levine AS, Lan L

    J Biol Chem 293:1353-1362

    DOI

  • ROS-induced R loops trigger a transcription-coupled but BRCA1/2-independent homologous recombination pathway through CSB

    Teng Y, Yadav T, Duan M, Tan J, Xiang Y, Gao B, Xu J, Liang Z, Liu Y, Nakajima S, Shi Y, Levine AS, Zou L, Lan L

    Nat Commun 9:4115

    DOI

  • Quantifying site-specific chromatin mechanics and DNA damage response

    Whitefield DB, Spagnol ST, Armiger TJ, Lan L, Dahl KN

    Sci Rep 8:18084

    DOI

2017

  • POT1 inhibits the efficiency but promotes the fidelity of nonhomologous end joining at non-telomeric DNA regions

    Yu Y, Tan R, Ren Q, Gao B, Sheng Z, Zhang J, Zheng X, Jiang Y, Lan L, Mao Z

    Aging (Albany NY) 9:2529-2543

    DOI

  • Cleavage of Ku80 by caspase-2 promotes non-homologous end joining-mediated DNA repair

    Yan Q, Zhu H, Lan L, Yi J, Yang J

    DNA Repair (Amst) 60:18-28

    DOI

  • SSRP1 Cooperates with PARP and XRCC1 to Facilitate Single-Strand DNA Break Repair by Chromatin Priming

    Gao Y, Li C, Wei L, Teng Y, Nakajima S, Chen X, Xu J, Leger B, Ma H, Spagnol ST, Wan Y, Dahl KN, Liu Y, Levine AS, Lan L

    Cancer Res 77:2674-2685

    DOI

  • WRN is recruited to damaged telomeres via its RQC domain and tankyrase1-mediated poly-ADP-ribosylation of TRF1

    Sun L, Nakajima S, Teng Y, Chen H, Yang L, Chen X, Gao B, Levine AS, Lan L

    Nucleic Acids Res 45:3844-3859

    DOI

  • Tankyrase1-mediated poly(ADP-ribosyl)ation of TRF1 maintains cell survival after telomeric DNA damage

    Yang L, Sun L, Teng Y, Chen H, Gao Y, Levine AS, Nakajima S, Lan L

    Nucleic Acids Res 45:3906-3921

    DOI

  • EAF2 regulates DNA repair through Ku70/Ku80 in the prostate

    Ai J, Pascal LE, Wei L, Zang Y, Zhou Y, Yu X, Gong Y, Nakajima S, Nelson JB, Levine AS, Lan L, Wang Z

    Oncogene 36:2054-2065

    DOI

  • Nek7 Protects Telomeres from Oxidative DNA Damage by Phosphorylation and Stabilization of TRF1

    Tan R, Nakajima S, Wang Q, Sun H, Xue J, Wu J, Hellwig S, Zeng X, Yates NA, Smithgall TE, Lei M, Jiang Y, Levine AS, Su B, Lan L

    Mol Cell 65:818-831.e5

    DOI

  • Induction of Site-Specific Oxidative Damage at Telomeres by Killerred-Fused Shelretin Proteins

    Tan R, Lan L

    Methods Mol Biol 1587:139-146

    DOI

2016

  • The Lys63-deubiquitylating Enzyme BRCC36 Limits DNA Break Processing and Repair

    Ng HM, Wei L, Lan L, Huen MS

    J Biol Chem 291:16197-207

    DOI

2015

  • Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway

    Xing M, Yang M, Huo W, Feng F, Wei L, Jiang W, Ning S, Yan Z, Li W, Wang Q, Hou M, Dong C, Guo R, Gao G, Ji J, Zha S, Lan L, Liang H, Xu D

    Nat Commun 6:6233

    DOI

  • Tyrosine 370 phosphorylation of ATM positively regulates DNA damage response

    Lee HJ, Lan L, Peng G, Chang WC, Hsu MC, Wang YN, Cheng CC, Wei L, Nakajima S, Chang SS, Liao HW, Chen CH, Lavin M, Ang KK, Lin SY, Hung MC

    Cell Res 25:225-36

    DOI

  • Differential phosphorylation of DNA-PKcs regulates the interplay between end-processing and end-ligation during nonhomologous end-joining

    Jiang W, Crowe JL, Liu X, Nakajima S, Wang Y, Li C, Lee BJ, Dubois RL, Liu C, Yu X, Lan L, Zha S

    Mol Cell 58:172-85

    DOI

  • RAD6 promotes homologous recombination repair by activating the autophagy-mediated degradation of heterochromatin protein HP1

    Chen S, Wang C, Sun L, Wang DL, Chen L, Huang Z, Yang Q, Gao J, Yang XB, Chang JF, Chen P, Lan L, Mao Z, Sun FL

    Mol Cell Biol 35:406-16

    DOI

  • SIRT6 protein deacetylase interacts with MYH DNA glycosylase, APE1 endonuclease, and Rad9-Rad1-Hus1 checkpoint clamp

    Hwang BJ, Jin J, Gao Y, Shi G, Madabushi A, Yan A, Guan X, Zalzman M, Nakajima S, Lan L, Lu AL

    BMC Mol Biol 16:12

    DOI

  • Interplay between arginine methylation and ubiquitylation regulates KLF4-mediated genome stability and carcinogenesis

    Hu D, Gur M, Zhou Z, Gamper A, Hung MC, Fujita N, Lan L, Bahar I, Wan Y

    Nat Commun 6:8419

    DOI

  • Fast and Precise 3D Fluorophore Localization based on Gradient Fitting

    Ma H, Xu J, Jin J, Gao Y, Lan L, Liu Y

    Sci Rep 5:14335

    DOI

  • Regulation of DNA Damage Signaling and Cell Death Responses by Epstein-Barr Virus Latent Membrane Protein 1 (LMP1) and LMP2A in Nasopharyngeal Carcinoma Cells

    Wasil LR, Wei L, Chang C, Lan L, Shair KH

    J Virol 89:7612-24

    DOI

  • Targeted DNA damage at individual telomeres disrupts their integrity and triggers cell death

    Sun L, Tan R, Xu J, LaFace J, Gao Y, Xiao Y, Attar M, Neumann C, Li GM, Su B, Liu Y, Nakajima S, Levine AS, Lan L

    Nucleic Acids Res 43:6334-47

    DOI

  • DNA damage during the G0/G1 phase triggers RNA-templated, Cockayne syndrome B-dependent homologous recombination

    Wei L, Nakajima S, Böhm S, Bernstein KA, Shen Z, Tsang M, Levine AS, Lan L

    Proc Natl Acad Sci U S A 112:E3495-504

    DOI

  • ARID1A Deficiency Impairs the DNA Damage Checkpoint and Sensitizes Cells to PARP Inhibitors

    Shen J, Peng Y, Wei L, Zhang W, Yang L, Lan L, Kapoor P, Ju Z, Mo Q, Shih IeM, Uray IP, Wu X, Brown PH, Shen X, Mills GB, Peng G

    Cancer Discov 5:752-67

    DOI

2014

  • Ubiquitin-specific protease 5 is required for the efficient repair of DNA double-strand breaks

    Nakajima S, Lan L, Wei L, Hsieh CL, Rapić-Otrin V, Yasui A, Levine AS

    PLoS One 9:e84899

    DOI

  • Damage-dependent regulation of MUS81-EME1 by Fanconi anemia complementation group A protein

    Benitez A, Yuan F, Nakajima S, Wei L, Qian L, Myers R, Hu JJ, Lan L, Zhang Y

    Nucleic Acids Res 42:1671-83

    DOI

  • Novel method for site-specific induction of oxidative DNA damage reveals differences in recruitment of repair proteins to heterochromatin and euchromatin

    Lan L, Nakajima S, Wei L, Sun L, Hsieh CL, Sobol RW, Bruchez M, Van Houten B, Yasui A, Levine AS

    Nucleic Acids Res 42:2330-45

    DOI

  • A Chemical Probe Targets DNA 5-Formylcytosine Sites and Inhibits TDG Excision, Polymerases Bypass, and Gene Expression

    Xu L, Chen YC, Nakajima S, Chong J, Wang L, Lan L, Zhang C, Wang D

    Chem Sci 5:567-574

    DOI

  • HSP90 regulates DNA repair via the interaction between XRCC1 and DNA polymerase β

    Fang Q, Inanc B, Schamus S, Wang XH, Wei L, Brown AR, Svilar D, Sugrue KF, Goellner EM, Zeng X, Yates NA, Lan L, Vens C, Sobol RW

    Nat Commun 5:5513

    DOI

2013

  • Damage response of XRCC1 at sites of DNA single strand breaks is regulated by phosphorylation and ubiquitylation after degradation of poly(ADP-ribose)

    Wei L, Nakajima S, Hsieh CL, Kanno S, Masutani M, Levine AS, Yasui A, Lan L

    J Cell Sci 126:4414-23

    DOI

2012

  • Monoubiquitinated histone H2A destabilizes photolesion-containing nucleosomes with concomitant release of UV-damaged DNA-binding protein E3 ligase

    Lan L, Nakajima S, Kapetanaki MG, Hsieh CL, Fagerburg M, Thickman K, Rodriguez-Collazo P, Leuba SH, Levine AS, Rapić-Otrin V

    J Biol Chem 287:12036-49

    DOI

2011

  • Mutant Cockayne syndrome group B protein inhibits repair of DNA topoisomerase I-DNA covalent complex

    Horibata K, Saijo M, Bay MN, Lan L, Kuraoka I, Brooks PJ, Honma M, Nohmi T, Yasui A, Tanaka K

    Genes Cells 16:101-14

    DOI

  • BRCA1 contributes to transcription-coupled repair of DNA damage through polyubiquitination and degradation of Cockayne syndrome B protein

    Wei L, Lan L, Yasui A, Tanaka K, Saijo M, Matsuzawa A, Kashiwagi R, Maseki E, Hu Y, Parvin JD, Ishioka C, Chiba N

    Cancer Sci 102:1840-7

    DOI

2010

  • DNA polymerase beta-dependent long patch base excision repair in living cells

    Asagoshi K, Liu Y, Masaoka A, Lan L, Prasad R, Horton JK, Brown AR, Wang XH, Bdour HM, Sobol RW, Taylor JS, Yasui A, Wilson SH

    DNA Repair (Amst) 9:109-19

    DOI

  • The ACF1 complex is required for DNA double-strand break repair in human cells

    Lan L, Ui A, Nakajima S, Hatakeyama K, Hoshi M, Watanabe R, Janicki SM, Ogiwara H, Kohno T, Kanno S, Yasui A

    Mol Cell 40:976-87

    DOI

2008

  • A polycomb group protein, PHF1, is involved in the response to DNA double-strand breaks in human cell

    Hong Z, Jiang J, Lan L, Nakajima S, Kanno S, Koseki H, Yasui A

    Nucleic Acids Res 36:2939-47

    DOI

  • Recruitment of mismatch repair proteins to the site of DNA damage in human cells

    Hong Z, Jiang J, Hashiguchi K, Hoshi M, Lan L, Yasui A

    J Cell Sci 121:3146-54

    DOI

  • Rapid recruitment of BRCA1 to DNA double-strand breaks is dependent on its association with Ku80

    Wei L, Lan L, Hong Z, Yasui A, Ishioka C, Chiba N

    Mol Cell Biol 28:7380-93

    DOI

2007

  • DNA single-strand break repair is impaired in aprataxin-related ataxia

    Hirano M, Yamamoto A, Mori T, Lan L, Iwamoto TA, Aoki M, Shimada K, Furiya Y, Kariya S, Asai H, Yasui A, Nishiwaki T, Imoto K, Kobayashi N, Kiriyama T, Nagata T, Konishi N, Itoyama Y, Ueno S

    Ann Neurol 61:162-74

    DOI

  • RAD18 and poly(ADP-ribose) polymerase independently suppress the access of nonhomologous end joining to double-strand breaks and facilitate homologous recombination-mediated repair

    Saberi A, Hochegger H, Szuts D, Lan L, Yasui A, Sale JE, Taniguchi Y, Murakawa Y, Zeng W, Yokomori K, Helleday T, Teraoka H, Arakawa H, Buerstedde JM, Takeda S

    Mol Cell Biol 27:2562-71

    DOI

  • A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses

    Kanno S, Kuzuoka H, Sasao S, Hong Z, Lan L, Nakajima S, Yasui A

    EMBO J 26:2094-103

    DOI

  • Werner syndrome protein interacts functionally with translesion DNA polymerases

    Kamath-Loeb AS, Lan L, Nakajima S, Yasui A, Loeb LA

    Proc Natl Acad Sci U S A 104:10394-9

    DOI

2006

  • BLM is an early responder to DNA double-strand breaks

    Karmakar P, Seki M, Kanamori M, Hashiguchi K, Ohtsuki M, Murata E, Inoue E, Tada S, Lan L, Yasui A, Enomoto T

    Biochem Biophys Res Commun 348:62-9

    DOI

  • Vertebrate POLQ and POLbeta cooperate in base excision repair of oxidative DNA damage

    Yoshimura M, Kohzaki M, Nakamura J, Asagoshi K, Sonoda E, Hou E, Prasad R, Wilson SH, Tano K, Yasui A, Lan L, Seki M, Wood RD, Arakawa H, Buerstedde JM, Hochegger H, Okada T, Hiraoka M, Takeda S

    Mol Cell 24:115-25

    DOI

  • Replication-dependent and -independent responses of RAD18 to DNA damage in human cells

    Nakajima S, Lan L, Kanno S, Usami N, Kobayashi K, Mori M, Shiomi T, Yasui A

    J Biol Chem 281:34687-95

    DOI

2005

  • Translocation of XRCC1 and DNA ligase IIIalpha from centrosomes to chromosomes in response to DNA damage in mitotic human cells

    Okano S, Lan L, Tomkinson AE, Yasui A

    Nucleic Acids Res 33:422-9

    DOI

  • DNA polymerase lambda protects mouse fibroblasts against oxidative DNA damage and is recruited to sites of DNA damage/repair

    Braithwaite EK, Kedar PS, Lan L, Polosina YY, Asagoshi K, Poltoratsky VP, Horton JK, Miller H, Teebor GW, Yasui A, Wilson SH

    J Biol Chem 280:31641-7

    DOI

2004

  • Functional and physical interactions between ERCC1 and MSH2 complexes for resistance to cis-diamminedichloroplatinum(II) in mammalian cells

    Lan L, Hayashi T, Rabeya RM, Nakajima S, Kanno Si, Takao M, Matsunaga T, Yoshino M, Ichikawa M, Riele Ht, Tsuchiya S, Tanaka K, Yasui A

    DNA Repair (Amst) 3:135-43

    DOI

  • In situ analysis of repair processes for oxidative DNA damage in mammalian cells

    Lan L, Nakajima S, Oohata Y, Takao M, Okano S, Masutani M, Wilson SH, Yasui A

    Proc Natl Acad Sci U S A 101:13738-43

    DOI

  • UV light-induced DNA damage and tolerance for the survival of nucleotide excision repair-deficient human cells

    Nakajima S, Lan L, Kanno S, Takao M, Yamamoto K, Eker AP, Yasui A

    J Biol Chem 279:46674-7

    DOI

2003

  • Spatial and temporal cellular responses to single-strand breaks in human cells

    Okano S, Lan L, Caldecott KW, Mori T, Yasui A

    Mol Cell Biol 23:3974-81

    DOI