Understanding how cancer cells maintain chromosome ends and exploit telomere-maintenance pathways.
We study telomere-associated DNA damage and repair, telomeric R-loops, replication stress, telomerase-dependent and alternative telomere-maintenance mechanisms, and their potential therapeutic vulnerabilities.
Telomeres
TERT
ALT
Telomeric R-loops
DNA Repair
Three routes of transcription-coupled homologous recombination at a break inside an active gene. Yang and Lan, FEBS Letters 2025.
Key publications
ZNF280A links DNA double-strand break repair to human 22q11.2 distal deletion syndrome
Clarke TL, Cho HM, Ceppi I, Gao B, Yadav T, Silveira GG, Boon R, Martinez-Pastor B, Amoh NYA, Machin B, Bernasocchi T, Ashfaq D, Mendez J, Kamaliyan Z, Del Río Pantoja J, Rogines GS, Crowley BT, McGinn DE, Giunta V, Tran O, Zackai EH, Lan L, Zou L, Emanuel BS, McDonald-McGinn DM, Cejka P, Mostoslavsky R
