Connecting genome instability and DNA damage with innate immunity and tumor-immune interactions.
We investigate both canonical immune functions and nuclear and chromatin-associated functions of cGAS, including its roles in DNA repair and replication.
We are particularly interested in how genome instability activates immune signaling and influences cancer progression and therapeutic response.
cGAS
STING
Innate Immunity
DNA Damage
DNA Replication
Tumor Immunity
Immunotherapy
cGAS binds PARP1 at a damaged active gene and restricts microhomology-mediated end joining; cGAS-null cells depend on PARP1 and become sensitive to PARP and TOP1 inhibitors. Yang et al., Cell Death & Differentiation 2026.
Key publications
ATM counteracts chromatin-bound cGAS during DNA replication
Song Y, Ran X, Xu Y, Subramanian K, Dai C, Konstantinos M, Lan L, Yadav V, Zou L
